Green Biotec UG Bremen Germany
Epigenetics and Gene Regulation
| Epigenetics and Gene Regulation | |
|---|---|
| Course Description | Epigenetic processes, including DNA methylation, histone modification, and various RNA-mediated processes, influence gene expression primarily at the transcriptional level. This course outlines the role of epigenetics in gene regulation and its impact on health and disease. Students will explore theoretical and practical aspects of analyzing DNA methylation and histone modifications. |
| Recommended Books | 1. Turner BM. Chromatin and Gene Regulation: Molecular Mechanisms in Epigenetics. John Wiley and Sons; 2008. 2. Mandal SS, editor. Gene Regulation, Epigenetics, and Hormone Signaling. John Wiley & Sons; 2017. |
| Course Learning Outcomes | After completing this course, students will be able to: 1. Understand the fundamental principles of epigenetics and its role in gene regulation. 2. Analyze the role of DNA methylation, histone modification, and RNA-based mechanisms in regulating gene expression. 3. Investigate the interactions of chromatin-modifying complexes and their biological significance. 4. Assess the implications of epigenetics in health and disease. |
| Assessment System | Quizzes: 10-15% Assignments: 5-10% Midterms: 30-40% End Semester Exam: 40-50% |
| Lecture Plan | ||
|---|---|---|
| S.No. | Description | Quizzes/Assignment |
| 1 | Introduction to Epigenetics and Gene Expression | |
| 2 | DNA Methylation and Epigenetic Regulation of Gene Expression | Quiz 1 |
| 3 | DNA Methyltransferases (DNMTs) and Their Functions | |
| 4 | DNMT Interaction with Transcription Factors | Assignment 1 |
| 5 | DNA Methylation and Methyl-Binding Proteins | |
| 6 | Histones and Epigenetic Regulation of Gene Expression | |
| 7 | Histone Modifications and Gene Expression | Quiz 2 |
| 8 | RNA-Based Mechanisms and Epigenetic Regulation | |
| 9 | Small Non-Coding RNAs in Epigenetic Regulation | Assignment 2 |
| 10 | Long Non-Coding RNAs and Their Functions | |
| 11 | Long-Term Silencing of Gene Expression | |
| 12 | Heterochromatin: Structure and Function | Quiz 3 |
| 13 | Chromatin Remodelling Machines | |
| 14 | Interaction of lncRNAs with Chromatin-Modifying Complexes | Assignment 3 |
| 15 | Applications of Epigenetics in Health and Disease | |
