Molecular Oncology
Course description:
Molecular Oncology is an integrated basic science program composed of a diverse
group of investigators with strengths in cancer stem cells, DNA damage repair and genomic
instability, tumor-host interactions, and other fundamental areas of cancer biology.
Recommended Books:
Bronchud MH, Foote MA, Giaccone G, Olopade O, Workman P, editors. Principles of
molecular
oncology. New Jersey:: Humana Press; 2008.
Prerequisite:
1. Essential of Genetics
Course Learning Outcomes:
After the course the students should be able to: describe general principles of cancer
diagnostics
and treatment, understand the basic processes underlying the transformation of a
normal cell to its
malignant counterpart, and the consequences of malignant transformation on the
cellular and
organism level, understand how the biological knowledge of cancer development is
used in
modern cancer treatment, show knowledge of laboratory techniques used in
experimental cancer
research, demonstrate knowledge in biostatistics and cancer epidemiology.
Assessment system:
Quizzes 10-15%
Assignments 5-10%
MSE 30-40%
ESE 40-50%
Lecture Plan:
S.NO. Lecture Topic Quizzes Assignments
1 Introduction to Molecular Oncology
2 Molecular Markers
Selecting the Right Targets for Cancer Therapy
3 Clinical Importance of Prognostic Factors: Moving from
Scientifically Interesting to Clinically Useful
4 Cellular and Tissue Markers in Solid Tumors 2
5 Growth Factor-Signaling Pathways in Cancer
6 Estrogen Action and Breast Cancer 2
7 Cyclin-Dependent Kinases and Their Regulators as
Potential Targets for Anticancer Therapeutics
8 Apoptosis Pathways: Clinical Relevance 3
10 DNA Repair Pathways: Mechanisms and Defects in the
Maintenance of Genome Stability
11 Angiogenesis Switch Pathways 3
12 Invasion and Metastasis
13 Molecular Pathways of Drug Resistance 4
14 Antitumor Immunity as Therapy for Human Cancer
15 Emerging Technologies: Molecular Targets and the Drug
Delivery Process
16 Emerging Molecular Therapies for Cancer
17 Emerging Molecular Therapies: Small-Molecule Drug
