Foundation course-BS (All disciplines of Biological Sciences)

·         To develop general understanding of microbial control.

·         To examine various factors that influence microbial control.

Mode of action mechanisms of antimicrobes

Resistance mechanisms

Emerging technology in the fields of antimicrobial agents

·         Basic strategies for drug discovery: Empirical screening, Molecular targets and developing models.

·         Range of antimicrobial targets.

·         Molecular basis for selective action against the prokaryotes.

·         Antimicrobial agents affecting: Cell wall synthesis, Protein Synthesis, DNA and RNA synthesis, Membrane and energy synthesis.

·         Antifungal drugs.

·         Mechanism of action of antiviral drugs.

·         Antiparasitic agents.

·         Resistance mechanisms.

·         New approaches in Therapy: By the use of Blockers for: selective microbial enzymes, substrates, and receptors.

·         Emerging antimicrobial technology.

2. Preparation of antibiotic discs.

3. McFarland standard preparation.

4. Bacterial lawn preparation.

5. Antibiotic susceptibility testing and interpretation.

6. Determination of minimum inhibitory concentration.

7. Determination of minimum bactericidal concentration.

8. Antibacterial activity of plant extracts.

 Written Assignments.

 Class activities and discussion.Practical hands on practice or video demonstration

Mid Term (40%)

 Written (Long Questions, Short Questions, MCQs)

 Project/case study/Presentation

 Assignments

 Tests/Quiz. / Viva

Final Term (60%)

 Written (Long Questions, Short Questions, MCQs).

2.   Finch, R., Davey, P., Wilcox, M.H., Irving, W., 2012. Antimicrobial Chemotherapy. Oxford University Press.

3.   Franklin, T.J., Snow, G.A., 2010. Biochemistry and Molecular Biology of Antimicrobial Drug Action. 6th Edition. Springer-Verlag New York,LL.

4.   Greenwood, D., Finch, R., Davey, P., Wilcox, M., 2007. Antimicrobial Chemotherapy. Oxford University Press; 5Rev Ed edition.

5.   Hauser, A. R., 2007. Antibiotic Basics for Clinicians. Wolters Kluwer Health.

Total working hours=180                Credit points=6CP