Green Biotec UG Bremen Germany
Development of Anticancers
| Development of Anticancers | |
|---|---|
| Course Description | This course offers an in-depth exploration of cancer therapeutics, focusing on the mechanisms of drug development. The course covers genomic foundations, preclinical and clinical research stages, drug discovery methods, and computational techniques used in cancer treatment development. Students will gain knowledge of the key targets for cancer drug development and explore advanced therapeutic strategies. By the end of the course, participants will be well-equipped to analyze and understand the intricate processes of cancer drug discovery, with a particular focus on cutting-edge treatments. |
| Recommended Books | 1. Cancer Drug Design and Discovery by J.M. Walker 2. Cancer Chemotherapy by H. A. P. Tisdale 3. Molecular Biology of Cancer by R. A. Weinberg |
| Course Learning Outcomes | After completing this course, a student will be able to: 1. Understand the basic principles and history of cancer therapeutics and genomics 2. Identify key targets for cancer drug discovery 3. Explore the process of drug development, from discovery to clinical testing 4. Apply computational methods in drug design for cancer treatment 5. Analyze the latest advancements in cancer treatment, including immunotherapy and gene editing |
| Assessment System | Quizzes: 10-15% Assignments: 5-10% Midterms: 30-40% ESE: 40-50% |
| Lecture Plan | ||
|---|---|---|
| S.No. | Description | Quizzes/Assignment |
| 1 | Introduction to Cancer and its Genomics: History, DNA topology, and drug targets for cancer therapy | |
| 2 | Anticancer Drug Target Prediction: Basic features of databases and their role in cancer-specific target identification | Assignment 1 |
| 3 | Discovery of Cancer Drugs: Accidental discovery, biosimilars, and plant-based drugs | |
| 4 | Challenges in Phase 1 Clinical Trials: Issues in efficacy, genome-driven approaches, and blood-based treatments | |
| 5 | Biosynthetic Products for Anticancer Drug Design: Bryostatins and their role in tumors | Quiz 1 |
| 6 | Drug Resistance Pathways: Targeting drug transport, cellular stress, and DNA repair systems | |
| 7 | mTOR Signaling in Cancer Drug Development: Tumor cell proliferation, angiogenesis, and biomarkers | |
| 8 | Recent Advances in Cancer Drug Development: Immunotherapy, CAR T cells, and CRISPR | Quiz 2 |
| 9 | High-Throughput Screening Assays: Methods for discovering anti-cancer compounds | |
| 10 | Transcriptomics of Cancer: Role in drug discovery and identifying molecular pathways | Assignment 2 |
| 11 | Genetic Perturbation Screens: Exploring genetic factors in cancer drug discovery | |
| 12 | Computational Methods in Cancer Drug Discovery: Introduction to computational techniques and MD simulations | Quiz 3 |
| 13 | Structure and Ligand-Based Drug Discovery: Techniques in computational drug design | |
| 14 | Genes Involved in Cancer: Case studies of ovarian and breast cancer | |
| 15 | Novel Drugs and Future Challenges: FDA-approved drugs, their targets, and mechanisms | Final Exam |
