Antimicrobial resistance
Course Content
- Introducing AMR
- Isolating & Identifying Bacteria
- Antimicrobial Susceptibility Testing
- Testing for Mechanisms of Resistance
- Quality Assurance & AMR Surveillance
- Introducing a One Health Approach to AMR
- An Introduction to AMR Surveillance
- AMR Surveillance
- The Problem of AMR
- Introducing AMR Surveillance Systems
- Legal & Ethical Considerations in AMR
- Fundamentals of Data for AMR
- Processing & Analyzing AMR data
- Summarizing & Presenting AMR data
- Diagnostic Stewardship in Clinical Practice
- Resistance mechanisms.
- Therapeutic implication of cytokines and vaccines.
- New approaches in Therapy: By the use of Blockers for: selective microbial enzymes, substrates, and receptors.
- Blockers for biochemical processes.
- Action of antibiotics on biofilms,
Emerging antimicrobial technology.
OBJECTIVES:
- To understand the mechanisms of chemotherapy in relation to AMR
- To develop general understanding of microbial control and controlling of AMR
- To examine various factors that influence microbial resistance
Practical
- Isolation of antibiotic resistant bacteria from environment.
- Effect of antibiotics on peptidoglycan content.
- Effect of antibiotics on total soluble protein content.
- Determination of extended spectrum beta lactamase in bacteria resistant to beta lactam antibiotics.
- Determination of protein profile of antibiotic sensitive and resistant bacteria by Polyacrylamide Gel Electrophoresis (PAGE).
- Effect of antibiotic on bacteria present in biofilm.
Recommended Books
- Hauser, A. R., 2007. Antibiotic Basics for Clinicians. Wolters Kluwer Health
- Greenwood, D., Finch, R., Davey, P., Wilcox ,M., 2007.Antimicrobial Chemotherapy. Oxford University Press; 5Rev Ed edition.
- Franklin, T.J., Snow, G.A., 2017. Biochemistry and Molecular Biology of Antimicrobial Drug Action. 6th Edition. Springer-Verlag New York, LL.
- Amyes, S., 2010 Antibacterial Chemotherapy: Theory Problems, and Practice. Publisher: Oxford University Press, USA. 5. Finch, R., Davey, P. Wilcox, M. H., Irving , W., 2012. Antimicrobial Chemotherapy. Oxford University Press.
