Green Biotec UG Bremen Germany
Systems Biology
| Systems Biology | |
|---|---|
| Course Description | Systems biology is the computational and mathematical modeling of complex biological systems. It is an interdisciplinary field that focuses on understanding complex interactions within biological systems using a holistic approach. This course introduces the study of interactions between components of biological systems and explores how these interactions give rise to system functions and behaviors, such as enzyme activity and metabolic pathways. |
| Recommended Books | 1. Klipp, E., Wolfram L., Christoph W., Axel K., Hans L., and Ralf H., “Systems Biology,” Wiley. 2. Ullah, M., and Olaf W., “Stochastic Approaches in Systems Biology,” Springer. 3. Newman, M., “Networks: An Introduction,” Oxford University Press, USA. 4. Alon, U., “An Introduction to Systems Biology: Design Principles of Biological Circuits,” Chapman Hall/CRC. |
| Course Learning Outcomes | After completing this course, students will be able to: 1. Understand the fundamental principles of systems biology and its applications. 2. Model biochemical systems using computational and mathematical techniques. 3. Analyze high-throughput data and interpret gene expression models. 4. Explore stochastic modeling and biological networks to study their structure, dynamics, and functions. |
| Assessment System | Quizzes: 10-15% Assignments: 5-10% Midterms: 30-40% End Semester Exam: 40-50% |
| Lecture Plan | ||
|---|---|---|
| S.No. | Description | Quizzes/Assignment |
| 1 | Introduction to Systems Biology | |
| 2 | Modeling of Biochemical Systems | Quiz 1 |
| 3 | Kinetic Modeling of Enzymatic Reactions | |
| 4 | Law of Mass Action | |
| 5 | Michaelis-Menten Kinetics | |
| 6 | Rate Equations and Their Applications | Assignment 1 |
| 7 | Model Systems: lac Operon, Phages, Plasmids, Chemotaxis | Quiz 2 |
| 8 | Analysis of High Throughput Data | |
| 9 | Gene Expression Models | |
| 10 | Stochastic Modeling of Biological Systems | Assignment 2 |
| 11 | Chemical Master Equation and Stochastic Simulation | |
| 12 | Fluctuations in Gene Expression | Quiz 3 |
| 13 | Biological Networks: Structure and Dynamics | |
| 14 | Network Motifs and Modularity | Assignment 3 |
| 15 | Applications of Systems Biology in Research and Medicine | |
